Why was Jessica neglected by her father and brother?

They blamed her for their mother's death since birth.

What triggers Jessica's disappearance?

A terminal cancer diagnosis after years of abuse.

Silent Sorrow

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Silent Sorrow — Years of familial blame end in tragedy when a terminally ill woman takes her own life.

Since birth, Jessica has carried the weight of her mother's death, enduring coldness from her father and hostility from her brother Elliot. Only Ava offers genuine kinship. A terminal cancer diagnosis drives Jessica to disappear, ending years of mistreatment. Elliot discovers the truth too late, finding her gone on her birthday by her own hand. Consumed by guilt, he faces the irreversible cost of his indifference, while Ava pledges a future reunion, unaware Jessica simply longed to be her little sister once more.

Quick answers

Why was Jessica neglected by her father and brother?: They blamed her for their mother's death since birth.
What triggers Jessica's disappearance?: A terminal cancer diagnosis after years of abuse.