Who are the main antagonists causing trouble for Grace?

Alice from the orphanage and Mrs. Reese.

A Little Angel in the Dragon Mansion

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A Little Angel in the Dragon Mansion — An orphan with healing magic joins a secretive dragon billionaire family and overcomes hostility from her new relatives and an old rival.

Grace, an orphan who possesses healing magic, misses adoption by the wealthy Reese family when her friend Alice traps her in a room. She is subsequently taken in by the Rose family, a powerful dragon clan living in the town's most mysterious billionaire estate. Her new life proves difficult: adoptive mother Linda and sister Lucy are sharp-tongued and cruel, while second brother Felix is physically disabled and eccentric. Meanwhile, Alice and Mrs. Reese continually scheme to destroy Grace's fresh start. Through kindness and courage, Grace gradually wins the Rose family's acceptance.

Quick answers

What special ability does Grace have?: Grace possesses healing magic.
Who are the main antagonists causing trouble for Grace?: Alice from the orphanage and Mrs. Reese.