What triggers Esme's decision to leave her husband?

He abandons her during a family crisis to stay with his mistress.

How does the husband react once Esme tries to leave?

He begs her to stay and tries to stop her departure.

May We Never Meet Again

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May We Never Meet Again — A neglected wife finally walks out after her husband chooses his mistress during a family emergency.

Esme Quinn tolerates three years of marital silence while her husband publicly dotes on another woman. When a sudden family emergency demands his attention, he abandons Esme to manage the fallout alone and remains with his mistress instead. The betrayal shatters her remaining hope, and she decides to leave the marriage for good. Only after she packs her bags and prepares to go does he reappear, begging her to stay and forcing her to confront whether any foundation remains to rebuild upon.

Quick answers

What triggers Esme's decision to leave her husband?: He abandons her during a family crisis to stay with his mistress.
How does the husband react once Esme tries to leave?: He begs her to stay and tries to stop her departure.